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    Develop a tool for

    Vizualizing Brain Cells

    SINCE.2020

    글 번호카테고리제목작성일
    4랩소식
    석사후/박사후 연수연구원 모집
    		2021-01-11
    3랩소식
    대학생 대상, 학점인정 현장실습 교육과정 참여 가능
    		2020-08-04
    2랩소식
    블러그와 연동 되었습니다.
    		2020-08-03
    1랩소식
    게시판이 개설되었습니다
    1    		2020-07-29

    border_color글쓰기

    ABOUT VizBrCells


    뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

    미지의 뇌세포를 손쉽게 볼 수 있는

    시각화 도구들을 만들고자 합니다.

    OUR Scheme


    1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

    2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

    3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

    4. 세포 특이적 염색의 분자 메커니즘의 분석

    ABOUT VizBrCells

     

    뇌를 알기 위해, 그리고 뇌질환의 관리를 위해

    미지의 뇌세포를 손쉽게 볼 수 있는

    시각화 도구들을 만들고자 합니다.

     

    SCHEME

     

                             1. 뇌세포 다양성에 기반한 소형 형광화합물 라이브러리 스크리닝으로 추적 물질 신규 발굴

                             2. 분자/세포생물학적 방법으로 후보화합물의 타깃 뇌세포 특징 연구

                             3. 타깃 뇌세포의 기능을 적용한 신경생물학적 연구

                             4. 세포 특이적 염색의 분자 메커니즘의 분석 

    account_circle

    COLLABORATION

    Through active co-work with chemists, novel  fluorescent probes have synthesized

    assignment

    CREDENTIAL

    By applying a creative screening platform, we give own ID to an unsung chemical

    public

    CONTRIBUTION

    After identifying its brain target, we can provide an innovative tool for tracking a type of brain cells

    Primary glial culture

    Microglia (CDr20)

     Nuclei (Hoechst33342)

    Primary glial culture

    1. Normal condition

    2, 3. ADP treat

      1. Phase contrast

      2. CDr20 fluorescence

    OUR TEAM

    We are the bridge of science.

    (Click image for more details)

    Lab Head, 김범수 (Beomsue Kim, Ph.D.)

     

    20-Current, Senior Researcher, Neural Circuit Group, Korea Brain Research Insisisute (KBRI)

    14-19, Research Fellow, Singapore Bioimaging Consortium, A-STAR, Singapore

    13-14, Research Fellow, Dpt. Chemistry, NUS, Singapore

    09-13, Research Fellow, Dpt. Pharmacology, Ajou University

    05-09, Ph.D., Neural Science & Technology, Ajou University, Korea

    03-04, Visiting Scholar, Dpt. Pediatrics, UTHSC, TN, USA

    01-03, M.Sc, Life Science, Hanyang University, Korea

    97-01, B.Sc., Biology, Hanyang University, Korea

    If you are interested to join us as a research fellow (MSc/PhD holder) or a gradurate student,

    please send e-mail with your CV  to kimbs@kbri.re.kr.

    PROJECT

    SINCE.2020~

     

                                                                       1. 소교세포의 세포소기관 관찰법 개발 (Microglial specific fluorescent probe & Click chemistry)

                                                                       2. 인간 뇌세포 추적기술 개발 (A human brain cell type-specific probe)

                                                                       3. 3차원 인간 뇌조직 배양체 유도 (iPSC-derived brain organoid)

    PUBLICATIONS


    LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition. Animal Cells Syst. 2022 Dec 22;26(6):380-387. Kim B#, Suh YH, Joe E#

    Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library. RSC Chem. Biol. 2021 Aug 20;2(6): 1590-1593. co-author

    A brief review of non-invasive brain imaging technologies and the near-infrared optical bioimaging.  Applied Miscroscopy 2021 51, Article number: 9.  Kim B*, Kim H, Kim S, Hwang Y

    A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2.   J Am Chem Soc. 2019 Sep 18;141(37):14673-14686.   Kim JJ, Lee YA, Su D, Lee J, Park SJ, Kim B, Jane Lee JH, Liu X, Kim SS, Bae MA, Lee JS, Hong SC, Wang L, Samanta A, Kwon HY, Choi SY, Kim JY, Yu YH, Ha HH, Wang Z, Tam WL, Lim B, Kang NY, Chang YT. 

    Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate.   Angew Chem Int Ed Engl. 2019 Jun 11;58(24):7972-7976.   Kim B#, Fukuda M#, Lee JY, Su D, Sanu S, Silvin A, Khoo ATT, Kwon T, Liu X, Chi W, Liu X, Choi S, Wan DSY, Park SJ, Kim JS, Ginhoux F, Je HS, Chang YT. (Frontispiece, VIP)

    Development of a Universal Fluorescent Probe for Gram-Positive Bacteria.   Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8426-8431.    Kwon HY, Liu X, Choi EG, Lee JY, Choi SY, Kim JY, Wang L, Park SJ, Kim B, Lee YA, Kim JJ, Kang NY, Chang YT.

    Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target.   Nat Commun. 2019 Mar 7;10(1):1111.   Park SJ#, Kim B#, Choi S#, Balasubramaniam S, Lee SC, Lee JY, Kim HS, Kim JY, Kim JJ, Lee YA, Kang NY, Kim JS, Chang YT.

    A Fluorescent Probe for Neural Stem/Progenitor Cells with High Differentiation Capability into Neurons.   Chembiochem. 2016 Nov 17;17(22):2118-2122.   Kim B, Feng S, Yun SW, Leong C, Satapathy R, Wan SY, Chang YT. (Front Cover)


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    From Tistory

    Alumni
    NamePositionPeriodCurrent
    황영란석사후연수연구원 (M.Sc)2020.05-2022.11Ph.D. student
    장규림연구인턴2021.01-2021.02DIGIST student
    김홍민박사후연수연구원 (Ph.D)2020.10-2020.12Company
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    ADRESS

    61, Cheomdan-ro, Dong-gu, Daegu, 41062. Korea

     

    PHONE NUMBER

    053-980-8480

     

    E-MAIL

    kimbs@kbri.re.kr

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